PHARMACOLOGY

Below is a partial list of drugs that block hERG. They are sorted by drug type.

Cardiovascular Diseases

Drug Name Brand Name
Amiodarone Pacerone, Cordarone
Bepridil  Vascor
Disopyramide Norpace
Dofetilide Tikosyn
Dronedarone New drug
Flecainide Tambocor
Ibutilide Corvert
Lidoflazine Clinium
Lignocaine Xylocaine, Xylocard Low Potency
Procainamide Pronestyl, Procan
Propafenone Rythmol
Quinidine Quinaglute, Cardioquin
Sotalol Betapace, Sotalex

Neuropsychiatric Diseases

Drug Name Brand Name  
Amitriptyline Elavil, Tryptizol
Buprenophine Subutex, Suboxone
Citalopram Celexa, Citalopram-Mepha
Clozapine Clozaril
Doxepin Sinquan
Droperidol Inapsine
Fluoxetine Sarafem, Prozac, Fluctine
Fluvoxamine Luvox, Faverine, Fevarin, Dumyrox
Haloperidol  Haldol, Sigaperidol
Imipramine Norfranil, Tofranil
Methadone Dolophine, Methadose, Ketalgin
Nortriptyline Pamelor, Nortrilen
Olanzapin Zyprexa
Pimozide Orap
Quetiapine Seroquel
Risperidone Risperdal
Sertindol Serdolect
Thioridazine Mellaril, Melleretten
Venlafaxine Effexor
Ziprasidone Geodon

Antihistamine

Drug Name Brand Name
Astemizole Hismanal
Clemastine Tavist, dayhist, anti-hist
Loratidine Clarytin
Terfenadine Seldane

Cancer Leukemia

Drug Name Brand Name
Arsenic trioxide Trisenox  
Tamoxifen Nolvadex  

Bacterial Infection

Drug Name Brand Name
Azithromycin Zithromax  
Ciprofloxacin Ciproflox, Ciproxin Low Potency
Clarithromycin Biaxin, Klacid  
Erythromycin Erythrocin, Karex, E.E.S.®  
Gatifloxacin Tequin  
Gemifloxacin Factive Low Potency
Levofloxacin Levaquin, Tavanic  
Moxifloxacin Avelox  
Ofloxacin Floxin, Tarivid Low Potency
Roxithromycin Rulide  
Sparfloxacin Zagam  
Telithromycin Ketek  

Parasitic Infections

Drug Name Brand Name
Chloroquine Arelan, Nivaquine, Chlorochin  
Halofantrine Halfan  
Mefloquin Lariam, Mephaquin  

Gastrointestinal Disease

Drug Name Brand Name
Cisapride Propulsid  
Dolasetron Anzemet  
Domperidone Motilium  
Granisetron Kytril  
Ondansetron Zofran  

Local Anesthetics

Drug Name Brand Name
Cocaine Cocaine  

Fungal Infections

Drug Name Brand Name
Ketoconazole Nizoral  

Malarial Infections

Drug Name Brand Name
Halofantrine Halfan  

Pneumonia

Drug Name Brand Name
Pentamidine Nebupent, Pentam, Pentacarinat Low Potency

Chronic Angina

Drug Name Brand Name
Ranolazine Ranexa  

Bladder Antispasmodic

Drug Name Brand Name
Tolterodine Detrol  

Phosphodiesterase inhibitor

Drug Name Brand Name
Sildenafil Viagra  
Tadalafil Cialis  
Vardenafil Levitra  

Alpha-adrenergic blocker

Drug Name Brand Name
Alfuzosin Uroxatral, Xatral  

Viral Infections

Drug Name Brand Name
Amantadine Symmetrel